Phosphorylation regulates human oct4

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August undefined, 2024

WebAdditionally, phosphorylation of human OCT4 at Ser-229 by protein kinase A might partially regulate OCT4 transactivation activity (13). OCT4 is also a target for SUMO1 (small ubiquitin-related modifier 1) modification that occurs at a … WebMay 25, 2024 · Several post-translational modifications (PTMs) of Oct4 including phosphorylation, ubiquitination, and SUMOylation have been reported to regulate its critical functions in hESCs. Ubiquitination and deubiquitination of Oct4 should be well balanced to maintain the pluripotency of hESCs.

Phosphorylation regulates human OCT4. DrugBank Online

WebOct 5, 2024 · Phosphorylation of threonine 343 mediates global OCT4-phosphorylation (phos-OCT4 T343) • Phos-OCT4 T343 is crucial for OCT4 to protect embryonic stem cell pluripotency • Phos-OCT4 T343 binds to SOX2 but non-phos-OCT4 T343 binds to SOX17 in cell fate decision • Phos-OCT4 T343 may regulate lineage commitment in early embryonic … how to submit t4s to cra

Inaugural Article: Phosphorylation regulates human OCT4

WebNov 2, 2012 · Recent analysis of the human ES cell phosphoproteome indicates that OCT4 is phosphorylated ( 6 ), but the functional consequences of these modifications have not been determined. In addition, limited data are available on the mechanisms regulating the nuclear entry of OCT4 and how its nuclear localization is linked to signaling pathways. WebApr 2, 2012 · We conclude that phosphorylation of T234 and S235 regulates OCT4 transcription primarily by altering its DNA binding capacity. Reprogramming experiments … WebPhosphorylation regulates human OCT4. Brumbaugh J, Hou Z, Russell JD, Howden SE, Yu P, Ledvina AR, Coon JJ, Thomson JA Proc Natl Acad Sci U S A. 2012 May 8;109(19):7162-8. reading london train

Addgene: Phosphorylation regulates human OCT4.

Posttranslational Regulation Of Key Transcription Factors In ...

WebNov 18, 2024 · Furthermore, OCT4 and SOX2 are regulated by O‐GlcNAcylation [ 20] and SOX2 has been demonstrated to be regulated by acetylation [ 21 ]. To investigate how NANOG acts through partner proteins to deliver function, we determined the NANOG interactome [ 22 ]. WebPhosphorylation regulates human OCT4. Proc Natl Acad Sci U S A. 2012 May 8;109(19):7162-8. doi: 10.1073/pnas.1203874109. Epub 2012 Apr 2. PubMed ID. 22474382 [ View in PubMed] Abstract. The transcription factor OCT4 is fundamental to maintaining pluripotency and self-renewal. To better understand protein-level regulation of OCT4, we … how to submit t4s online to craWebMay 8, 2012 · We conclude that phosphorylation of T234 and S235 regulates OCT4 transcription primarily by altering its DNA binding capacity. Reprogramming experiments … reading long stay car park

"WebPhosphorylation of T234 and S235 on OCT4 Regulates DNA Binding. Phosphorylation sites on OCT4 were scattered throughout the protein (Fig. 1A); however, two sites (T234 and … " - Phosphorylation regulates human oct4

Phosphorylation regulates human oct4

The Oct4 protein: more than a magic stemness marker - PMC

WebMay 14, 2024 · OCT4 phosphorylation at the S111 residue by MK2 was upstream of MYC transcriptional activation. ... J. et al. Phosphorylation regulates human OCT4. ... Avery, K., Moore, H. D. & Andrews, P. W ... WebFeb 4, 2024 · 2.1. PGC7 Regulates Genome-Wide DNA Methylation in F9 and NIH3T3 Cells. Previous studies have reported that PGC7 can regulate DNA methylation [14,15,16,17,18].We first evaluated the effects of PGC7 by knocking down Pgc7 in F9 cells and used SiPgc7-FAM, a green fluorescent dye marker, to determine genome-wide 5 mC levels following …

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WebJun 11, 2024 · Oct4 expression is regulated by two cis-enhancer elements (distal and proximal enhancers) that are located 2 kb upstream of its transcriptional start site 63, 64. Interestingly, the activity of... WebSep 5, 2014 · Critical amounts of human Oct4-IA are required to sustain stem cell self-renewal and it has been shown that Oct4-IB is not related to stemness. In humans, Oct4 …

WebDec 12, 2024 · Based on recent studies, we expected that the JNK-mediated phosphorylation of OCT4 would regulate its intracellular stability. To examine whether … WebSep 28, 2012 · Finally, we identified several signaling pathways which may mediate this phosphorylation and act in combination to regulate Oct4 transcriptional activity and …

WebPhosphorylation regulates human OCT4 Author: Brumbaugh, Justin, Hou, Zhonggang, Russell, Jason D., Howden, Sara E., Yu, Pengzhi, Ledvina, Aaron R., Coon, Joshua J., … WebFunctional analysis of two sites, T234 and S235, suggested that phosphorylation within the homeobox region of OCT4 negatively regulates its activity by interrupting sequence …

WebFunctional analysis of two sites, T234 and S235, suggested that phosphorylation within the homeobox region of OCT4 negatively regulates its activity by interrupting sequence …

WebApr 2, 2012 · OCT4 is phosphorylated on serine 12 in ESCs Phosphorylation of OCT4 by kinases provides a potential mechanism to regulate OCT4 activity through signaling … reading logs printable free for 6th gradeWebDec 12, 2024 · Our data thus suggest that phosphorylation of serine 347 regulates OCT4 protein stability and proteasomal degradation in mouse ESCs. Results OCT4 Is a Substrate of JNK1 and JNK2 Recent studies indicated that PTMs regulate the function of transcription factors, including Sox2, Klf4, and Oct4 ( Cai et al., 2012). how to submit tax return electronicallyWebthat OCT4 activity might be regulated by post-translational modifications, specifically phosphorylation. OCT4A sequence analysis conducted with the database PhosphoMotif … reading long a sound phrasesWebJan 1, 2024 · OCT4 (also known as Oct3 and Oct3/4), which is encoded by Pou5f1, is expressed in early embryonic cells and plays an important role in early development, … reading lop 3WebJan 1, 2024 · These PTMs play essential roles in regulating the structure, activity, and localization of the OCT4 protein and its interactions with other cellular components. The … reading lop 11WebJan 29, 2014 · MG132, a proteasome inhibitor, blocked LY294002-induced Oct4 reduction, indicating that Oct4 protein level is regulated by PI3K/Akt signaling via proteasome-dependent mechanism. Furthermore, analysis of Oct4 protein sequence revealed that it contained a consensus Akt phosphorylation motif. reading lop 12WebFIGURE 4 OCT4A Ser-111 phosphorylation regulates OCT4A subcellular localization. A, NTera2 cells were serum-starved and then treated with FGF2 (100 ng/ml) for 30 min in the … reading london road