Phorbol myristyl acetate
WebMar 31, 2024 · Phorbol 12-myristate-13-acetate (16561-29-8) activates protein kinase C (10-100 ng/ml)1. May display PKC-independent effects in various cell types2. Warning: Phorbol 12-myristate-13-acetate is a skin irritant. Avoid contact with this compound. Chemical Properties white to off-white solid Uses WebBiological Activity. Phorbol 12-myristate 13-acetate is an extensively used phorbol ester high affinity activator of protein kinase C (K = 2.6 nM as …
Phorbol myristyl acetate
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WebPhorbol 12-myristate 13-acetate is a phorbol ester. It works as a tumor promoter and is involved in gene transcription, cell growth, differentiation, programmed cell death, immune … WebPhorbol 12-myristate 13-acetate (PMA), also known as 12-O-tetradecanoylphorbol 13-acetate (TPA), is a phorbol ester and PKC activator. 1, 2, 3, 4, 5 It activates the PKC isoforms PKCα, -β, -γ, -δ, -ε, -η, and -θ but not PKCζ or -ι/λ. 2 PMA (1-10 ng/ml) induces NF-κB-dependent gene expression in a reporter assay. 3 It promotes the differentiation …
WebPhorbol-12-myristate-13-acetate-induced protein 1 is a protein that in humans is encoded by the PMAIP1 gene, and is also known as Noxa. [3] [4] [5] Noxa (Latin for damage) is a pro- apoptotic member of the Bcl-2 protein family. [6] WebDescription. PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA …
WebPhorbol 12-myristate 13-acetate (PMA), PKC activator (DMSO solution) Description PKC activator (DMSO solution) Alternative names PMA Biological description Potent nanomolar activator of protein kinase C in vivo and in vitro. Binds to C1 domain of protein kinase C, induces membrane translocation and enzyme activation. WebMay 1, 2001 · In some experiments, U937 cells were incubated with pure flavonoid or plasma extract in a 25-mL culture flask (Becton Dickinson Labware) for 20 h, activated with phorbol myristyl acetate (PMA; 100 μg/L) for 2 h, and then fluorescently labeled.
WebMyristyl acetate Catalog NO.: B0001-130590 CAS NO.: 638-59-5 Brand: BOC Sciences Category Main Product Molecular Formula C16H32O2 Molecular Weight 256.42 Request another packsize? Click Bulk Order. BULK ORDER ADD TO CART FLASH CHECKOUT Specification Purity 95% Appearance Clear Colourless Oily Liquid Synonyms
WebMar 25, 2024 · THP-1 cells were seeded into the upper insert of a 6-well Transwell apparatus (0.4 μm pore size, Corning, Lowell, MA, USA) and treated them with Phorbol myristyl acetate (PMA) (320 nM, P1585, Sigma-Aldrich, St. Louis, MO, … how many bpm is staying aliveWebJan 1, 1998 · To explore this, we prepared human peripheral blood mononuclear cells by plastic adherence from whole-blood buffy-coat fractions, and induced cytokine synthesis using phorbol myristyl acetate (PMA). high protein cold lunch meal prep meatlessWeb12-O-Tetradecanoylphorbol-13-acetate ( TPA ), also commonly known as tetradecanoylphorbol acetate, tetradecanoyl phorbol acetate, and phorbol 12-myristate 13 … high protein coffee shakeWebWe found that the invariant natural killer T cells in the lungs of patients with asthma produced both interleukin-4 and interleukin-13 but little interferon-γ on intracellular cytokine staining... high protein cookbookWebThe choice of phorbol 12-myristate 13-acetate differentiation protocol influences the response of THP-1 macrophages to a pro-inflammatory stimulus. The human monocytic … high protein cookbook scott baptieWebMay 3, 2013 · Lane 1: Daudi (human Burkitt's lymphoma lymphoblast) treated with 50 ng/ml phorbol-12-myristate-13-acetate (PMA, ab120297) for 24 hours whole cell lysate 10 µg … high protein corn seedhow many bpm is thunderstruck