WebThe endoribonuclease IRE1/ERN1 encodes the ER-to-nucleus signaling 1 protein, a human homolog of the yeast Ire1 gene product. In S. cerevisiae, as well as in human, this ER transmembrane IRE serine/threonine protein kinase monitors the status of unfolded proteins inside the ER lumen in response to stress. ... Molecular Weight: The recombinant ... WebN-terminal 6His-tagged, recombinant, human IRE1 amino acids 465-end expressed by baculovirus in Sf21 insect cells. Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez Gene Number: NM_001433; Gene Symbol: ERN1; IRE1; UniProt Number: O75460; Molecular Weight: 62 kDa

MKC8866 IRE1 TargetMol

WebApr 17, 2024 · The relationship between the molecular weight of PVDF and its distribution, phase separation, crystallization behavior and spinning process has been systematically studied. The effects of three factors on the microstructure and properties of the PVDF membrane have been analyzed. The flow behaviors of the PVDF/diluent and PVDF melt … WebIRE1 Inhibitor III, 4μ8C - CAS 14003-96-4 - Calbiochem. IRE1 Inhibitor III, CAS 14003-96-4, is a cell-permeable. Covalent inhibitor of IRE1 RNase activity (IC₅₀ = 550 and 45 nM, … hometown markets philipsburg pa

IRE1 Inhibitor IV, A-106 Sigma-Aldrich

WebOct 15, 2024 · Here, we combine protein-protein docking with molecular dynamics simulations to derive human IRE1 tetramer models and identify a molecular mechanism … WebMolecular weight (Da) 107792.5 Theoretical pI 5.90 IRE1 Protein Structure Crystal structure of the Human kinase and RNase domains in complex with ADP Deposited 2010-10-01 … WebIRE1 has an isoelectric point at pH 7.63 and a molecular weight of 49,970.48 g/mol. IRE1 signals for activation of the unfolded protein response (UPR) pathway when there is a buildup of misfolded proteins in the endoplasmic reticulum (5). The N-terminal luminal domain (NLD) of IRE1 functions as an ER stress sensor. hometown market wadley al