WebMay 18, 2006 · The B-cell lymphoma/leukemia 11A (BCL11A) gene was first identified in the rare t(2;14)(p16;q32.3) translocation in aggressive B-cell chronic lymphocytic leukemia and, together with REL, is a ... WebNov 15, 2013 · The zinc-finger protein BCL11A is a major modulator of hemoglobin switching and HbF silencing. BCL11A was initially identified by genome-wide association studies (GWAS) as a new HbF-associated gene. Down-regulation of BCL11A in primary human erythroid cells induces HbF expression.
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WebMar 1, 2012 · FOXO transcription factors induce apoptosis and regulate cellular production of reactive oxygen species (ROS). To identify the sequence of molecular events underlying FOXO3 (FKHRL1)-induced apoptosis, we studied the regulation and function of FOXO3 by expressing an ECFP-tagged FOXO3 or a 4OH-tamoxifen (4OHT)-inducible … Web5 FOXO and Neural Stem Cells. FOXO (FOXO3)-mediated redox balance and transcriptional control of metabolic genes is also implicated in the maintenance of neural stem cells (NSCs) (Paik et al., 2009; Renault et al., 2009; Yeo et al., 2013) (see also chapter “FOXO in neural cells and diseases of the nervous system” by Santo and Paik). charles owen halo round fit
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WebNov 15, 2013 · FOXO3 is involved in multiple cellular processes, including cell cycle arrest, removal of reactive oxygen species, and regulation of erythroid differentiation. Erythroid … WebForkhead box O3, also known as FOXO3 or FOXO3a, is a human protein encoded by the FOXO3 gene. [5] Function [ edit] FOXO3 belongs to the O subclass of the forkhead … WebMar 26, 2004 · Thus, FOXO3 acetylation appears to be specifically induced in response to oxidative stress stimuli. Consistent with this observation, we found that protein acetylases, including p300/CBP-associated factor (PCAF), interact with FOXO in a stress-inducible manner (fig. S1). Fig. 1. Interaction of SIRT1 and FOXO3 in response to oxidative stress. charles owen frederick