Dichloromethotrexate
WebTwenty-one patients with solid tumors were treated with weekly 6-h intravenous infusions of dichloromethotrexate (DCM), with escalating doses every other week. Frequently observed toxicities included leukopenia, thrombocytopenia, and mucositis. Nausea, vomiting, diarrhea, and elevation of hepatic enzymes and bilirubin occurred less often. WebDescribed herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of a
Dichloromethotrexate
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WebOct 23, 1980 · Hence, while dichloromethotrexate had the lowest for aldehyde oxidase amongst the 4-amino-antifolates studied, the actual rates of hydroxylation depended upon the concentration employed because of substrate inhibition. Aminopterin was a very poor substrate for this enzyme at low and saturating concentrations. These properties of the ... WebFind technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. Each entry includes links to find associated …
WebDOI: 10.1021/jo01291a034 Corpus ID: 95091409; Aromatic chlorination of p-aminobenzoic acid derivatives. Improved syntheses of mono- and dichloromethotrexate @article{Martinelli1980AromaticCO, title={Aromatic chlorination of p-aminobenzoic acid … WebSWOG-8308 Combination Cis-Platinum and Dichloromethotrexate Closed Phase Published Abbreviated Title Combination Cis-Platinum and Dichloromethotrexate Activated 10/18/1983 Closed 03/14/1986 Publication Information
WebA series of lipid-soluble dialkyl esters of methotrexate and 3',5'-dichloromethotrexate have been prepared and their properties as substrates for rabbit liver aldehyde oxidase and … WebApr 19, 2016 · A perennial bestseller, this third edition includes individual entries for over 300 compounds. The extensive list of references has been updated and includes entries for 15 pesticides commonly used...
WebJul 1, 1992 · The combination of cisplatin and dichloromethotrexate is a pharmacologically rational strategy designed to avoid the nephrotoxicity associated with the systemic …
WebDichloromethotrexate is a chlorinated methotrexate derivative. Dichloromethotrexate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylates and inhibiting DNA and RNA synthesis. This agent is … highbury \\u0026 islington councilWebThe distribution, excretion, and metabolism of radioactive dichloromethotrexate (DCM-Cl 36) following single parenteral and oral doses in the mouse, rat, rabbit and dog have been studied. highbury \u0026 islingtonWebDichloromethotrexate-resistant Lactobacillus casei* (Received for publication, June 4, 1970) THEODORE C. CRUSBERG, RICHARD LEARY, AND ROY L. KISLIUK From the Department of Biochemistry, Tufts ... how far is rathdrum from post fallsWebThe effects of human serum albumin (HA) on the cell growth inhibition produced by dichloromethotrexate (DCM) and methotrexate (MTX) and the reversibility by leucovorin (LV) of the cell growth inhibition induced by both agents were examined in vitro using a malignant human lymphocyte line, MOLT 3. The biological activity of DCM, which was ... how far is ratcliff ar from epping ndWebOct 23, 1980 · Plasma levels of methotrexate, dichloromethotrexate, and their 7-hydroxy metabolites can be determined quickly and accurately by direct analysis in a high … how far is rapid city sd from interior sdWebDichloromethotrexate, infusional cisplatin, and infusional 5-fluorouracil for locally advanced or metastatic non-small cell lung cancer. A MAOP study. Galen L. Wampler, James D. Ahlgren, Jacob J ... how far is rathdrum from coeur d\\u0027alenehow far is raton from denver